Harfi

GHRP-6

GHRP-6 is a synthetic agonist of ghrelin and growth hormone secretagogues. It has been shown to positively impact appetite, heart muscle cells, scar formation, and sexual motivation. Animal studies suggest that this orally active compound also enhances memory function and may help counteract the neurological effects of Parkinson’s disease.

Product Usage

This product is intended for research purposes only. It is strictly designated for in vitro testing and laboratory experimentation. All information provided on this website is for educational purposes only. Any introduction into humans or animals is strictly prohibited by law. Only licensed, qualified professionals should handle this product. It is not a drug, food, or cosmetic and must not be misbranded, misused, or mislabeled as such.

What Is GHRP-6?

GHRP-6 effectively stimulates the natural release of Growth Hormone from the anterior pituitary. As a ghrelin/growth hormone receptor agonist, it is one of several ghrelin analogues developed in recent decades. Research has shown that GHRP-6 offers various benefits, including supporting heart muscle cells, enhancing memory formation, influencing scar development, boosting sexual motivation, and protecting neurons associated with Parkinson’s disease. It is active when taken orally or sublingually and demonstrates moderate to high selectivity.

GHRP-6 Structure

Sequence: His-D-Trp-Ala-Trp-D-Phe-Lys
Molecular Formula: C46H56N12O6
Molecular Weight: 873.032 g/mol
PubChem CID: 9919153
CAS Number: 87616-84-0

GHRP-6 Effects

1. Enhances Memory

The connection between physical activity and cognitive function has been extensively studied. While the exact mechanisms remain unclear, there is strong evidence that exercise enhances learning and memory, particularly when performed immediately after a learning task.

Initially, the cognitive benefits of exercise were attributed to improved blood circulation and vague associations with growth hormone (GH). However, research in rodents has clarified GH’s role in memory formation, revealing that GHRP-6 can help consolidate newly acquired memories and facilitate the transition from short-term to long-term storage. Additionally, ghrelin and GHRP-6 have been strongly linked to spatial learning, suggesting that exercise-induced cognitive improvements may be driven by growth hormone secretagogues like ghrelin, with GH playing a secondary, indirect role.

2. Protects Brain Tissue

Studies using animal models of stroke have explored the neuroprotective effects of GHRP-6. Findings indicate that this peptide not only safeguards brain tissue during an acute stroke but also helps restore memory deficits when administered promptly.

GHRP-6 and its related compounds appear to inhibit apoptosis (programmed cell death) and reduce inflammation within the brain. By preventing neuronal loss and mitigating harmful environmental effects post-stroke, these peptides may provide significant therapeutic potential for brain injury and neurodegenerative conditions.

3. Protects Neurons in Parkinson’s Disease

A 2018 study highlighted the neuroprotective potential of GHRP-6 by revealing that ghrelin receptors are present in the substantia nigra, a brain region affected by Parkinson’s disease. Patients with genetic predispositions to Parkinson’s exhibit reduced expression of ghrelin receptors in this area. Similarly, rats with this defect develop Parkinson’s-like symptoms when given a ghrelin receptor antagonist. This suggests that agonists like GHRP-6 could help by binding to these diminished receptors, potentially reducing neuronal apoptosis and slowing or even preventing Parkinson’s progression.

4. Enhances Skin Health and Reduces Scarring

GHRP-6 has been shown to support cell survival by minimizing programmed cell death. It also interacts with the CD36 receptor, which plays a crucial role in promoting blood vessel growth, particularly in wound healing. Research in rats indicates that GHRP-6 accelerates wound closure, enhances extracellular matrix protein production (such as collagen), and helps regulate scar formation, leading to a more organized healing process with reduced visible scarring.

Additionally, GHRP-6 has been found to prevent hypertrophic scars, including keloids, which result from excessive extracellular matrix deposition. By inhibiting this abnormal healing process, the peptide offers potential benefits for individuals prone to severe scarring, helping them feel more confident in undergoing medical procedures or surgeries.

5. Supports Heart Health

Studies in porcine models of heart attacks suggest that GHRP-6 can protect heart cells from oxidative damage caused by free radicals. This discovery raises the possibility of developing post-heart attack treatments to safeguard vulnerable but still viable cardiac cells. Such a therapeutic approach could significantly improve survival rates and long-term outcomes for heart attack patients.

6. Influences Sexual Motivation and Mood

Research in male rats indicates that ghrelin receptors in the central nervous system influence sexual behavior and motivation. Higher ghrelin levels have been linked to increased sexual drive, and studies using GHRP-6 and its modified antagonist have demonstrated that ghrelin receptors in specific brain regions regulate sexual and reward-seeking behaviors. These findings may have implications not only for conditions like hypoactive sexual desire disorder but also for understanding hunger and other forms of motivation.

Moreover, there is evidence that ghrelin impacts mood regulation. Studies in mice suggest that GHRP-6 and other ghrelin receptor agonists can alleviate depression and enhance brain function, particularly in response to stress. This raises the potential for GHRP-6 to serve as the foundation for future research into novel treatments for stress, anxiety, depression, and related mood disorders.

GHRP-6 has demonstrated minimal to moderate side effects, low oral bioavailability, and excellent subcutaneous bioavailability in mice. However, dosage per kilogram in mice does not directly translate to human applications. GHRP-6 is available for purchase at Harfi exclusively for educational and scientific research purposes and is not intended for human consumption. Only licensed researchers should obtain GHRP-6 for study.

DISCLAIMER: FOR INFORMATIONAL AND EDUCATIONAL PURPOSES ONLY

All articles and product details provided on this website are strictly for informational and educational purposes.

The product information presented here applies solely to in-vitro studies—experiments conducted outside of living organisms, such as in laboratory settings. These products are not classified as medicines or drugs and have not been approved by the FDA for the prevention, treatment, or cure of any medical conditions, ailments, or diseases.

Furthermore, the use of these products in humans or animals is strictly prohibited by law.