CJC-1295 DAC

A Long-Acting Growth Hormone Secretagogue

CJC-1295 DAC is a synthetic analog of growth hormone-releasing hormone (GHRH), designed to stimulate the production of growth hormone (GH) and insulin-like growth factor 1 (IGF-1). The inclusion of Drug Affinity Complex (DAC) extends its half-life, allowing for prolonged effectiveness and sustained hormone release in the bloodstream.

Product Usage

This product is intended for research purposes only. It is strictly designated for in vitro testing and laboratory experimentation. All information provided on this website is for educational purposes only. Any introduction into humans or animals is strictly prohibited by law. Only licensed, qualified professionals should handle this product. It is not a drug, food, or cosmetic and must not be misbranded, misused, or mislabeled as such.

Introduction

Growth hormone-releasing hormone (GHRH) has undergone several modifications to develop analogs that enhance specific hormonal effects while minimizing others. One such advancement is CJC-1295, a synthetic peptide derived from the first 29 amino acids of GHRH. This modified version, a maleimido derivative of hGRF(1-29), was engineered to create a more stable and soluble GH secretagogue, enabling large-scale production while preserving the physiological functions of GHRH.

CJC-1295 vs. CJC-1295 DAC

CJC-1295 is a refined version of GHRH’s first 29 amino acids, closely resembling other GHRH analogs like Sermorelin and modified GRF (1-29). Despite these similarities, they are not identical, leading to frequent confusion—especially since CJC-1295 was initially developed with a specialized chemical modification known as the Drug Affinity Complex (DAC).

DAC, introduced via a lysine linker, enhances peptide stability by promoting its binding to albumin, a common blood protein. This extends the half-life of CJC-1295 in circulation, making it significantly more durable than comparable peptides like GRF (1-29).

Structure

Sequence: Tyr-D-Ala-Asp-Ala-Ile-Phe-Thr-Gln-Ser-Tyr-Arg-Lys-Val-Leu-Ala-Gln-Leu-Ser-Ala-Arg-Lys-Leu-Leu-Gln-Asp-Ile-Leu-Ser-Arg

Molecular Formula: C152H252N44O42

Molecular Weigh: 3367.954 g/mol

PubChem CID: 56841945

CJC-1295-DAC Research

Enhancing Growth Hormone Levels

As a GHRH derivative, CJC-1295 effectively stimulates the release of growth hormone (GH) in the body. Research indicates that a single dose can increase GH levels by 2 to 10 times in mice. This GH surge typically peaks around two hours after administration and remains active for approximately six days, highlighting the peptide’s prolonged effect.

Preserving Normal GH Release

Studies on mice with impaired GHRH physiology suggest that CJC-1295 helps maintain natural GH secretion. This indicates its potential for addressing growth abnormalities, both in mice and potentially in humans. Maintaining a pulsatile GH release is essential, as it ensures the proper regulation of insulin-like growth factor-1 (IGF-1), a key hormone involved in growth and metabolic processes.

CJC-1295 and Its Role in Addressing Infertility

Promoting Ovulation

Research from the early 1990s suggests that CJC-1295 and other GHRH analogs may play a role in promoting ovulation among infertile female patients. Ovulation is influenced by growth hormone (GH) and insulin-like growth factor-1 (IGF-1), both of which naturally rise during the ovulatory phase. Animal studies indicate that administering GH secretagogues, including CJC-1295, can potentially induce proper ovulation, offering a promising avenue for fertility research.

Exploring Male Infertility

While the link between CJC-1295 and female fertility is becoming clearer, researchers are also investigating its potential role in male infertility. Some speculate that this peptide may help regulate sperm production, though further studies are needed to confirm its effectiveness. Given its broad impact on growth regulation and reproductive health, CJC-1295 remains a subject of interest in scientific research.

CJC-1295 Summary

CJC-1295 is a growth hormone secretagogue engineered for an extended half-life, allowing it to mimic natural GH secretion patterns effectively. While interest in this molecule has fluctuated due to the emergence of similar compounds, its potential applications in reproductive health and growth regulation continue to attract attention.

CJC-1295 has shown moderate side effects, low oral bioavailability, and excellent subcutaneous absorption in mice. However, dosages in mice do not directly translate to humans. CJC-1295, available at Harfi, is strictly for educational and scientific research purposes and is not intended for human consumption. Only licensed researchers should purchase this peptide.

DISCLAIMER: FOR INFORMATIONAL AND EDUCATIONAL PURPOSES ONLY

All articles and product details provided on this website are strictly for informational and educational purposes.

The product information presented here applies solely to in-vitro studies—experiments conducted outside of living organisms, such as in laboratory settings. These products are not classified as medicines or drugs and have not been approved by the FDA for the prevention, treatment, or cure of any medical conditions, ailments, or diseases.